
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Resumen
El microbioma oral humano, integrado por más de 1000 especies bacterianas, desempeña un papel esencial en la salud oral y sistémica. Su desequilibrio, conocido como disbiosis, se asocia con patologías como caries, periodontitis y diversas condiciones sistémicas. El objetivo de esta revisión fue examinar, con base en la literatura científica, la relación entre la disbiosis oral y la salud humana, además de describir las técnicas moleculares empleadas para su análisis. Se realizó una búsqueda sistemática en PubMed (2000–2024) utilizando operadores booleanos y palabras clave relacionadas con microbiota oral, enfermedades orales y sistémicas, y técnicas moleculares. Se seleccionaron estudios en humanos que emplearan herramientas genómicas u ómicas, excluyendo revisiones y modelos animales. En total, se incluyeron 51 artículos que cumplían los criterios de elegibilidad. Los datos fueron organizados en una hoja estandarizada y analizados mediante Python 3.11.11 para identificar tendencias taxonómicas y metodológicas reportadas en la literatura.
Las familias más reportadas en los estudios analizados fueron Streptococcaceae, Prevotellaceae, Porphyromonadaceae, Fusobacteriaceae y Lactobacillaceae. Asi mismo, géneros como Streptococcus y Fusobacterium se asociaron con caries, mientras que Porphyromonas, Tannerella y Treponema se relacionaron con periodontitis. De igual manera, estas bacterias periodontopatógenas mostraron vínculos con enfermedades sistémicas como cáncer y procesos inflamatorios. La evidencia revisada resalta la importancia de caracterizar con precisión la microbiota oral y de incorporar enfoques moleculares avanzados, como la secuenciación de nueva generación y la metagenómica, para comprender este ecosistema y sus implicaciones clínicas.
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Anderson, A. C., Von Ohle, C., Frese, C., Boutin, S., Bridson, C., Schoilew, K., Peikert, S. A., Hellwig, E., Pelz, K., Wittmer, A., Wolff, D., & Al-Ahmad, A. (2023). The oral microbiota is a reservoir for antimicrobial resistance: resistome and phenotypic resistance characteristics of oral biofilm in health, caries, and periodontitis. Annals Of Clinical Microbiology And Antimicrobials, 22(1). https://doi.org/10.1186/s12941-023-00585-z
Bello-Corral, L., Alves-Gomes, L., Fernández-Fernández, J. A., Fernández-García, D., Casado-Verdejo, I., & Sánchez-Valdeón, L. (2023). Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer’s disease. Life Sciences, 333, 122132. https://doi.org/10.1016/j.lfs.2023.122132
Bertolini, M., Ranjan, A., Thompson, A., Diaz, P. I., Sobue, T., Maas, K., & Don-gari-Bagtzoglou, A. (2019). Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection. PLoS Pathogens, 15(4), e1007717. https://doi.org/10.1371/journal.ppat.1007717
Bosshardt, D. D. (2017). The periodontal pocket: pathogenesis, histopathol-ogy and consequences. Periodontology 2000, 76(1), 43-50. https://doi.org/10.1111/prd.12153
Brzychczy-Sroka, B., Talaga-Ćwiertnia, K., Sroka-Oleksiak, A., Gurgul, A., Zar-zecka-Francica, E., Ostrowski, W., Kąkol, J., Zarzecka, J., & Brzychczy-Włoch, M. (2023). Oral microbiota study of the patients after hospitalisation for COVID-19, considering selected dental indices and antibiotic therapy using the next generation sequencing method (NGS). Journal Of Oral Microbiology, 15(1). https://doi.org/10.1080/20002297.2023.2264591
Carelli, M., Maguolo, A., Zusi, C., Olivieri, F., Emiliani, F., De Grandi, G., Unali, I., Zerman, N., Signoretto, C., & Maffeis, C. (2023). Oral Microbiota in Children and Adolescents with Type 1 Diabetes Mellitus: Novel Insights into the Pathogenesis of Dental and Periodontal Disease. Microorganisms, 11(3), 668. https://doi.org/10.3390/microorganisms11030668
Carrouel, F., Kanoute, A., Lvovschi, V., & Bourgeois, D. (2023). Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium. Frontiers In Microbiology, 14. https://doi.org/10.3389/fmicb.2023.1275180
Chen, W., Chang, S., Tang, C., Liou, M., Tsai, S. J., & Lin, Y. (2018). Composition Analysis and Feature Selection of the Oral Microbiota Associated with Periodontal Disease. BioMed Research International, 2018, 1-14. https://doi.org/10.1155/2018/3130607
Chen, X., Daliri, E. B., Chelliah, R., & Oh, D. (2020). Isolation and Identification of Potentially Pathogenic Microorganisms Associated with Dental Caries in Human Teeth Biofilms. Microorganisms, 8(10), 1596. https://doi.org/10.3390/microorganisms8101596
Choi, S., Kim, K., Chang, J., Kim, S. M., Kim, S. J., Cho, H., & Park, S. M. (2019). Association of Chronic Periodontitis on Alzheimer’s Disease or Vascular Dementia. Journal Of The American Geriatrics Society, 67(6), 1234-1239. https://doi.org/10.1111/jgs.15828
Chu, X., Cao, N., Zhou, H., Meng, X., Guo, B., Zhang, H., & Li, B. (2020). The oral and gut microbiome in rheumatoid arthritis patients: a systematic review. Lara D. Veeken, 60(3), 1054-1066. https://doi.org/10.1093/rheumatology/keaa835
Cintrón, M., Hauser, J., Otto, C., Persing, D., & Tang, Y. (2014). Diagnostic Mi-crobiology. En Elsevier eBooks, 1-17 https://doi.org/10.1016/b978-0-12-801238-3.02392-8
Corrêa, J. D., Fernandes, G. R., Calderaro, D. C., Mendonça, S. M. S., Silva, J. M., Albiero, M. L., Cunha, F. Q., Xiao, E., Ferreira, G. A., Teixeira, A. L., Mukherjee, C., Leys, E. J., Silva, T. A., & Graves, D. T. (2019). Oral microbial dysbiosis linked to wors-ened periodontal condition in rheumatoid arthritis patients. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-44674-6
Del Campo-Moreno, R., Alarcón-Cavero, T., D’Auria, G., Delgado-Palacio, S., & Ferrer-Martínez, M. (2017). Microbiota en la salud humana: técnicas de caracteri-zación y transferencia. Enfermedades Infecciosas y Microbiología Clínica, 36(4), 241-245. https://doi.org/10.1016/j.eimc.2017.02.007
Del Giudice, C., Vaia, E., Liccardo, D., Marzano, F., Valletta, A., Spagnuolo, G., Ferrara, N., Rengo, C., Cannavo, A., & Rengo, G. (2021). Infective Endocarditis: A Focus on Oral Microbiota. Microorganisms, 9(6), 1218. https://doi.org/10.3390/microorganisms9061218
Deng, Z., Szafrański, S. P., Jarek, M., Bhuju, S., & Wagner-Döbler, I. (2017). Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-03804-8
Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W., Laksh-manan, A., & Wade, W. G. (2010). The human oral microbiome. Journal Of Bacteriolo-gy, 192(19), 5002-5017. https://doi.org/10.1128/jb.00542-10
Dhotre, S., Jahagirdar, V., Suryawanshi, N., Davane, M., Patil, R., & Nagoba, B. (2017). Assessment of periodontitis and its role in viridans streptococcal bacteremia and infective endocarditis. Indian Heart Journal, 70(2), 225-232. https://doi.org/10.1016/j.ihj.2017.06.019
Eren, A. M., Borisy, G. G., Huse, S. M., & Welch, J. L. M. (2014). Oligotyping analysis of the human oral microbiome. Proceedings Of The National Academy Of Sciences, 111(28). https://doi.org/10.1073/pnas.1409644111
Favale, N., Farina, R., Carrieri, A., Simonelli, A., Severi, M., Sabbioni, S., Trom-belli, L., & Scapoli, C. (2023). Functional profile of oral plaque microbiome: Further insight into the bidirectional relationship between type 2 diabetes and periodontitis. Molecular Oral Microbiology, 39(2), 62-79. https://doi.org/10.1111/omi.12418
Fernandes, G. V. O., Mosley, G. A., Ross, W., Dagher, A., Martins, B. G. D. S., & Fernandes, J. C. H. (2024). Revisiting Socransky’s Complexes: A Review Suggesting Updated New Bacterial Clusters (GF-MoR Complexes) for Periodontal and Peri-Implant Diseases and Conditions. Microorganisms, 12(11), 2214. https://doi.org/10.3390/microorganisms12112214
Flemer, B., Warren, R. D., Barrett, M. P., Cisek, K., Das, A., Jeffery, I. B., Hur-ley, E., O‘Riordain, M., Shanahan, F., & O‘Toole, P. W. (2017). The oral microbiota in colorectal cancer is distinctive and predictive. Gut, 67(8), 1454-1463. https://doi.org/10.1136/gutjnl-2017-314814
Frank, D. N., Qiu, Y., Cao, Y., Zhang, S., Lu, L., Kofonow, J. M., Robertson, C. E., Liu, Y., Wang, H., Levens, C. L., Kuhn, K. A., Song, J., Ramakrishnan, V. R., & Lu, S. (2022). A dysbiotic microbiome promotes head and neck squamous cell carcinoma. Oncogene, 41(9), 1269-1280. https://doi.org/10.1038/s41388-021-02137-1
Ganly, I., Hao, Y., Rosenthal, M., Wang, H., Migliacci, J., Huang, B., Katabi, N., Brown, S., Tang, Y., Pei, Z., & Yang, L. (2022). Oral Microbiome in Nonsmoker Patients with Oral Cavity Squamous Cell Carcinoma, Defined by Metagenomic Shotgun Se-quencing. Cancers, 14(24), 6096. https://doi.org/10.3390/cancers14246096
Gao, L., Xu, T., Huang, G., Jiang, S., Gu, Y., & Chen, F. (2018). Oral microbi-omes: more and more importance in oral cavity and whole body. Protein & Cell, 9(5), 488-500. https://doi.org/10.1007/s13238-018-0548-1
Gao, S., Zhang, Z., Sun, K., Li, M., & Qi, Y. (2023). Upper gastrointestinal tract microbiota with oral origin in relation to oesophageal squamous cell carcinoma. An-nals Of Medicine, 55(2). https://doi.org/10.1080/07853890.2023.2295401
Gilbert, J. A., & Neufeld, J. D. (2014). Life in a World without Microbes. PLoS Biology, 12(12), e1002020. https://doi.org/10.1371/journal.pbio.1002020
Giordano-Kelhoffer, B., Lorca, C., Llanes, J. M., Rábano, A., Del Ser, T., Serra, A., & Gallart-Palau, X. (2022). Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review. Biomedicines, 10(8), 1803. https://doi.org/10.3390/biomedicines10081803
Guo, X., Dai, S., Lou, J., Ma, X., Hu, X., Tu, L., Cui, J., Lu, H., Jiang, T., & Xu, J. (2023). Distribution characteristics of oral microbiota and its relationship with intesti-nal microbiota in patients with type 2 diabetes mellitus. Frontiers In Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1119201
Huang, R., Li, M., & Gregory, R. L. (2011). Bacterial interactions in dental bio-film. Virulence, 2(5), 435-444. https://doi.org/10.4161/viru.2.5.16140
Huang, S., He, T., Yue, F., Xu, X., Wang, L., Zhu, P., Teng, F., Sun, Z., Liu, X., Jing, G., Su, X., Jin, L., Liu, J., & Xu, J. (2021). Longitudinal Multi-omics and Microbiome Me-ta-analysis Identify an Asymptomatic Gingival State That Links Gingivitis, Periodontitis, and Aging. mBio, 12(2). https://doi.org/10.1128/mbio.03281-20
Huang, S., Yang, F., Zeng, X., Chen, J., Li, R., Wen, T., Li, C., Wei, W., Liu, J., Chen, L., Davis, C., & Xu, J. (2011). Preliminary characterization of the oral microbiota of Chinese adults with and without gingivitis. BMC Oral Health, 11(1). https://doi.org/10.1186/1472-6831-11-33
Ismail, A., Yogarajah, A., Falconer, J. L., Dworakowski, R., Watson, S., Breeze, J., Gunning, M., Khan, H., Hussain, A., Howard, J. P., Cheong, P., Shah, M., Nibali, L., & Sousa, V. (2024). Insights into microorganisms, associated factors, and the oral micro-biome in infective endocarditis patients. Frontiers In Oral Health, 5. https://doi.org/10.3389/froh.2024.1270492
Jiang, Y., Song, B., Brandt, B. W., Cheng, L., Zhou, X., Exterkate, R. A. M., Crielaard, W., & Deng, D. M. (2021). Comparison of Red-Complex Bacteria Between Saliva and Subgingival Plaque of Periodontitis Patients: A Systematic Review and Meta-Analysis. Frontiers In Cellular And Infection Microbiology, 11. https://doi.org/10.3389/fcimb.2021.727732
Kahharova, D., Pappalardo, V., Buijs, M., De Menezes, R., Peters, M., Jackson, R., Hara, A., Eckert, G., Katz, B., Keels, M., Levy, S., Zaura, E., Brandt, B., & Fontana, M. (2023). Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries. Journal Of Dental Research, 102(7), 759-766. https://doi.org/10.1177/00220345231160756
Karygianni, L., Ren, Z., Koo, H., & Thurnheer, T. (2020). Biofilm Matrixome: Extracellular Components in Structured Microbial Communities. Trends In Microbio-logy, 28(8), 668-681. https://doi.org/10.1016/j.tim.2020.03.016
Khalid, M., Hassani, D., Bilal, M., Butt, Z. A., Hamayun, M., Ahmad, A., Huang, D., & Hussain, A. (2017). Identification of oral cavity biofilm forming bacteria and de-termination of their growth inhibition by Acacia arabica , Tamarix aphylla L. and Melia azedarach L. medicinal plants. Archives Of Oral Biology, 81, 175-185. https://doi.org/10.1016/j.archoralbio.2017.05.011
Kilian, M., Chapple, I. L. C., Hannig, M., Marsh, P. D., Meuric, V., Pedersen, A. M. L., Tonetti, M. S., Wade, W. G., & Zaura, E. (2016). The oral microbiome – an update for oral healthcare professionals. BDJ, 221(10), 657-666. https://doi.org/10.1038/sj.bdj.2016.865
Korona-Glowniak, I., Piatek, D., Fornal, E., Lukowiak, A., Gerasymchuk, Y., Kedziora, A., Bugla-Płoskonska, G., Grywalska, E., Bachanek, T., & Malm, A. (2021). Patterns of Oral Microbiota in Patients with Apical Periodontitis. Journal Of Clinical Medicine, 10(12), 2707. https://doi.org/10.3390/jcm10122707
Kumar, M., Singh, P., Murugesan, S., Vetizou, M., McCulloch, J., Badger, J. H., Trinchieri, G., & Khodor, S. A. (2019). Microbiome as an Immunological Modifier. Methods In Molecular Biology, 595-638. https://doi.org/10.1007/978-1-4939-9773-2_27
Li, H., Wang, J., Wu, L., Luo, J., Liang, X., Xiao, B., & Zhu, Y. (2018). The im-pacts of delivery mode on infant’s oral microflora. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-30397-7
Litwack, G. (2021). Nucleic Acids and Molecular Genetics. En Elsevier eBooks (pp. 287-356). https://doi.org/10.1016/b978-0-323-85718-5.00010-8
Lourenςo, T. G. B., Spencer, S. J., Alm, E. J., & Colombo, A. P. V. (2018). Defin-ing the gut microbiota in individuals with periodontal diseases: an exploratory study. Journal Of Oral Microbiology, 10(1), 1487741. https://doi.org/10.1080/20002297.2018.1487741
Lu, H., Ren, Z., Li, A., Zhang, H., Jiang, J., Xu, S., Luo, Q., Zhou, K., Sun, X., Zheng, S., & Li, L. (2016). Deep sequencing reveals microbiota dysbiosis of tongue coat in patients with liver carcinoma. Scientific Reports, 6(1). https://doi.org/10.1038/srep33142
Lu, J., Zhang, S., Huang, Y., Qian, J., Tan, B., Qian, X., Zhuang, J., Zou, X., Li, Y., & Yan, F. (2022). Periodontitis-related salivary microbiota aggravates Alzheimer’s dis-ease via gut-brain axis crosstalk. Gut Microbes, 14(1). https://doi.org/10.1080/19490976.2022.2126272
Maier, T. (2023). Oral Microbiome in Health and Disease: Maintaining a Healthy, Balanced Ecosystem and Reversing Dysbiosis. Microorganisms, 11(6), 1453. https://doi.org/10.3390/microorganisms11061453
Manzoor, M., Leskelä, J., Pietiäinen, M., Martinez-Majander, N., Könönen, E., Niiranen, T., Lahti, L., Sinisalo, J., Putaala, J., Pussinen, P. J., & Paju, S. (2024). Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study. Journal Of Oral Microbiology, 16(1). https://doi.org/10.1080/20002297.2024.2330867
Marsh, P. D., & Zaura, E. (2017). Dental biofilm: ecological interactions in health and disease. Journal Of Clinical Periodontology, 44(S18). https://doi.org/10.1111/jcpe.12679
Mason, M. R., Preshaw, P. M., Nagaraja, H. N., Dabdoub, S. M., Rahman, A., & Kumar, P. S. (2014). The subgingival microbiome of clinically healthy current and nev-er smokers. The ISME Journal, 9(1), 268-272. https://doi.org/10.1038/ismej.2014.114
Matsha, T., Prince, Y., Davids, S., Chikte, U., Erasmus, R., Kengne, A., & Da-vison, G. (2020). Oral Microbiome Signatures in Diabetes Mellitus and Periodontal Disease. Journal Of Dental Research, 99(6), 658-665. https://doi.org/10.1177/0022034520913818
McManus, R. M., & Heneka, M. T. (2017b). Role of neuroinflammation in neurodegeneration: new insights. Alzheimer S Research & Therapy, 9(1). https://doi.org/10.1186/s13195-017-0241-2
Menon, T., Gopalakrishnan, S. N., Balasubramanian, R., & Justin, S. R. (2017). Characterisation of the Human Oral Microbiome in Patients with Coronary Artery Disease Using Next-generation Sequencing of 16SrRNA Amplicons. Indian Journal Of Medical Microbiology, 35(1), 101-104. https://doi.org/10.4103/ijmm.ijmm_16_370
Miles, B., Zakhary, I., El-Awady, A., Scisci, E., Carrion, J., O’Neill, J. C., Rawlings, A., Stern, J. K., Susin, C., & Cutler, C. W. (2013). Secondary Lymphoid Organ Homing Phenotype of Human Myeloid Dendritic Cells Disrupted by an Intracellular Oral Path-ogen. Infection And Immunity, 82(1), 101-111. https://doi.org/10.1128/iai.01157-13
Na, H. S., Jung, N., Song, Y., Kim, S. Y., Kim, H., Lee, J. Y., & Chung, J. (2023). A distinctive subgingival microbiome in patients with periodontitis and Alzheimer’s dis-ease compared with cognitively unimpaired periodontitis patients. Journal Of Clinical Periodontology, 51(1), 43-53. https://doi.org/10.1111/jcpe.13880
Nowicki, E. M., Shroff, R., Singleton, J. A., Renaud, D. E., Wallace, D., Drury, J., Zirnheld, J., Colleti, B., Ellington, A. D., Lamont, R. J., Scott, D. A., & Whiteley, M. (2018). Microbiota and Metatranscriptome Changes Accompanying the Onset of Gingivitis. mBio, 9(2). https://doi.org/10.1128/mbio.00575-18
Oba, P. M., Holscher, H. D., Mathai, R. A., Kim, J., & Swanson, K. S. (2020). Di-et Influences the Oral Microbiota of Infants during the First Six Months of Life. Nu-trients, 12(11), 3400. https://doi.org/10.3390/nu12113400
Olate, P., Martínez, A., Sans-Serramitjana, E., Cortés, M., Díaz, R., Hernández, G., Paz, E. A., Sepúlveda, N., & Quiñones, J. (2025). The Infant Oral Microbiome: De-velopmental Dynamics, Modulating Factors, and Implications for Oral and Systemic Health. International Journal Of Molecular Sciences, 26(16), 7983. https://doi.org/10.3390/ijms26167983
Peng, X., Cheng, L., You, Y., Tang, C., Ren, B., Li, Y., Xu, X., & Zhou, X. (2022). Oral microbiota in human systematic diseases. International Journal Of Oral Science, 14(1). https://doi.org/10.1038/s41368-022-00163-7
Pérez-Salcedo, L., & Martínez, A. B. (2010). Tumores benignos de la mucosa oral. Avances En Odontoestomatología, 26(1). https://doi.org/10.4321/s0213-12852010000100002
Rubinstein, T., Brickman, A. M., Cheng, B., Burkett, S., Park, H., Annavajhala, M. K., Uhlemann, A., Andrews, H., Gutierrez, J., Paster, B. J., Noble, J. M., & Papapanou, P. N. (2024). Periodontitis and brain magnetic resonance imaging markers of Alz-heimer’s disease and cognitive aging. Alzheimer S & Dementia, 20(3), 2191-2208. https://doi.org/10.1002/alz.13683
Saikia, P. J., Pathak, L., Mitra, S., & Das, B. (2023). The emerging role of oral microbiota in oral cancer initiation, progression and stemness. Frontiers In Immuno-logy, 14. https://doi.org/10.3389/fimmu.2023.1198269
Sánchez, M. C., Velapatiño, A., Llama‐Palacios, A., Valdés, A., Cifuentes, A., Ciudad, M. J., & Collado, L. (2022). Metataxonomic and metabolomic evidence of bio-film homeostasis disruption related to caries: An in vitro study. Molecular Oral Micro-biology, 37(2), 81-96. https://doi.org/10.1111/omi.12363
Sano, H., Wakui, A., Kawachi, M., Washio, J., Abiko, Y., Mayanagi, G., Yamaki, K., Tanaka, K., Takahashi, N., & Sato, T. (2021). Profiling system of oral microbiota utiliz-ing polymerase chain reaction-restriction fragment length polymorphism analysis. Journal Of Oral Biosciences, 63(3), 292-297. https://doi.org/10.1016/j.job.2021.05.003
Santacroce, L., Passarelli, P. C., Azzolino, D., Bottalico, L., Charitos, I. A., Caz-zolla, A. P., Colella, M., Topi, S., Godoy, F. G., & D’Addona, A. (2023). Oral microbiota in human health and disease: A perspective. Experimental Biology And Medicine, 248(15), 1288-1301. https://doi.org/10.1177/15353702231187645
Shi, M., Wei, Y., Hu, W., Nie, Y., Wu, X., & Lu, R. (2018). The Subgingival Mi-crobiome of Periodontal Pockets With Different Probing Depths in Chronic and Ag-gressive Periodontitis: A Pilot Study. Frontiers In Cellular And Infection Microbiology, 8. https://doi.org/10.3389/fcimb.2018.00124
Simón-Soro, A., & Mira, A. (2014). Solving the etiology of dental caries. Trends In Microbiology, 23(2), 76-82. https://doi.org/10.1016/j.tim.2014.10.010
Siqueira, J. F., & Rôças, I. N. (2022). The Oral Microbiota in Health and Dis-ease: An Overview of Molecular Findings. Methods In Molecular Biology, 61-73. https://doi.org/10.1007/978-1-0716-2780-8_5
Su, S., Chang, L., Huang, H., Peng, C., Chuang, C., Chen, Y., Lu, M., Chiu, Y., Chen, P., & Yang, S. (2020). Oral microbial dysbiosis and its performance in predicting oral cancer. Carcinogenesis, 42(1), 127-135. https://doi.org/10.1093/carcin/bgaa062
Su, S., Qi, T., Wang, W., Salama, E., & Li, Y. (2023). Investigation of the oral microbiome of children associated with dental caries: A systematic study. Archives Of Oral Biology, 154, 105776. https://doi.org/10.1016/j.archoralbio.2023.105776
Sukmana, B. I., Saleh, R. O., Najim, M. A., Al-Ghamdi, H. S., Achmad, H., Al-Hamdani, M. M., Taher, A. A., Alsalamy, A., Khaledi, M., & Javadi, K. (2024). Oral micro-biota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms. Frontiers In Oncology, 14. https://doi.org/10.3389/fonc.2024.1319777
Takahashi, N. (2015). Oral microbiome metabolism. Journal Of Dental Re-search, 94(12), 1628-1637. https://doi.org/10.1177/0022034515606045
Tanaka, Y., Yamashita, R., Kawashima, J., Mori, H., Kurokawa, K., Fukuda, S., Gotoh, Y., Nakamura, K., Hayashi, T., Kasahara, Y., Sato, Y., & Fukudo, S. (2022). Omics profiles of fecal and oral microbiota change in irritable bowel syndrome patients with diarrhea and symptom exacerbation. Journal Of Gastroenterology, 57(10), 748-760. https://doi.org/10.1007/s00535-022-01888-2
Tang, Y., Nie, H., Zhang, Y., Wei, Y., Huang, Y., Zhuang, Y., Yang, W., & Zhu, Y. (2024). Effects of Sjogren’s syndrome and high sugar diet on oral microbiome in pa-tients with rampant caries: a clinical study. BMC Oral Health, 24(1). https://doi.org/10.1186/s12903-024-04150-8
Tao, K., Yuan, Y., Xie, Q., & Dong, Z. (2024). Relationship between human oral microbiome dysbiosis and neuropsychiatric diseases: An updated overview. Behav-ioural Brain Research, 471, 115111. https://doi.org/10.1016/j.bbr.2024.115111
Tuganbaev, T., Yoshida, K., & Honda, K. (2022). The effects of oral microbiota on health. Science, 376(6596), 934-936. https://doi.org/10.1126/science.abn1890
Tuominen, H., & Rautava, J. (2020). Oral Microbiota and Cancer Develop-ment. Pathobiology, 88(2), 116-126. https://doi.org/10.1159/000510979
Uchino, Y., Goto, Y., Konishi, Y., Tanabe, K., Toda, H., Wada, M., Kita, Y., Bep-pu, M., Mori, S., Hijioka, H., Otsuka, T., Natsugoe, S., Hara, E., & Sugiura, T. (2021). Colo-rectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects. Cancers, 13(13), 3332. https://doi.org/10.3390/cancers13133332
Upadhyayula, R. S., Solanki, P. S., Suravajhala, P., & Medicherla, K. M. (2019). Bioinformatics Tools for Microbial Diversity Analysis. En Springer eBooks (pp. 23-47). https://doi.org/10.1007/978-981-13-8315-1_2
Vailati-Riboni, M., Palombo, V., & Loor, J. J. (2017). What are Omics Sciences? En Springer eBooks (pp. 1-7). https://doi.org/10.1007/978-3-319-43033-1_1
Vitkov, L., Singh, J., Schauer, C., Minnich, B., Krunić, J., Oberthaler, H., Gamsjaeger, S., Herrmann, M., Knopf, J., & Hannig, M. (2023). Breaking the Gingival Barrier in Periodontitis. International Journal Of Molecular Sciences, 24(5), 4544. https://doi.org/10.3390/ijms24054544
Vogtmann, E., Hua, X., Yu, G., Purandare, V., Hullings, A. G., Shao, D., Wan, Y., Li, S., Dagnall, C. L., Jones, K., Hicks, B. D., Hutchinson, A., Caporaso, J. G., Wheeler, W., Sandler, D. P., Beane Freeman, L. E., Liao, L. M., Huang, W.-Y., Freedman, N. D., Capo-raso, N. E., Sinha, R., Gail, M. H., Shi, J., & Abnet, C. C. (2022). The oral microbiome and lung cancer risk: An analysis of 3 prospective cohort studies. JNCI: Journal of the Na-tional Cancer Institute, 114(11), 1501–1510. https://doi.org/10.1093/jnci/djac149
Wang, B., Yao, M., Lv, L., Ling, Z., & Li, L. (2017). The Human Microbiota in Health and Disease. Engineering, 3(1), 71-82. https://doi.org/10.1016/j.eng.2017.01.008
Welch, J. L. M., Ramírez-Puebla, S. T., & Borisy, G. G. (2020). Oral Microbi-ome Geography: Micron-Scale Habitat and Niche. Cell Host & Microbe, 28(2), 160-168. https://doi.org/10.1016/j.chom.2020.07.009
Winning, L., & Linden, G. J. (2017). Periodontitis and Systemic Disease: Asso-ciation or Causality? Current Oral Health Reports, 4(1), 1-7. https://doi.org/10.1007/s40496-017-0121-7
Wolff, D., Frese, C., Schoilew, K., Dalpke, A., Wolff, B., & Boutin, S. (2019). Amplicon-based microbiome study highlights the loss of diversity and the establish-ment of a set of species in patients with dentin caries. PLoS ONE, 14(7), e0219714. https://doi.org/10.1371/journal.pone.0219714
World Health Organization. (2022) Informe sobre la situación mundial de la salud bucodental: Hacia la cobertura sanitaria universal para la salud bucodental de aquí a 2030. Resumen Ejecutivo.
Xi, R., Wang, R., Wang, Y., Xiang, Z., Su, Z., Cao, Z., Xu, X., Zheng, X., & Li, J. (2019). Comparative analysis of the oral microbiota between iron-deficiency anaemia (IDA) patients and healthy individuals by high-throughput sequencing. BMC Oral Health, 19(1). https://doi.org/10.1186/s12903-019-0947-6
Xiao, X., Liu, S., Deng, H., Song, Y., Zhang, L., & Song, Z. (2023). Advances in the oral microbiota and rapid detection of oral infectious diseases. Frontiers In Micro-biology, 14. https://doi.org/10.3389/fmicb.2023.1121737
Yadav, S., Tripathi, V., & Saran, V. (2023). Identification of habit specific bac-teria in human saliva through Next-Generation Sequencing. Forensic Science Interna-tional, 353, 111871. https://doi.org/10.1016/j.forsciint.2023.111871
Yamazaki, K., & Kamada, N. (2023). Exploring the oral-gut linkage: Interrela-tionship between oral and systemic diseases. Mucosal Immunology, 17(1), 147-153. https://doi.org/10.1016/j.mucimm.2023.11.006
Yost, S., Duran-Pinedo, A. E., Teles, R., Krishnan, K., & Frias-Lopez, J. (2015). Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. Genome Medicine, 7(1). https://doi.org/10.1186/s13073-015-0153-3
Yuan, B., Yeh, Y., Lin, C., Huang, C., Liu, H., & Chiang, C. (2020). Clinical Detec-tion of Chronic Rhinosinusitis through Next-Generation Sequencing of the Oral Mi-crobiota. Microorganisms, 8(6), 959. https://doi.org/10.3390/microorganisms8060959
Zhang, J., Sun, M., Zhao, Y., Geng, G., & Hu, Y. (2021b). Identification of Gingi-vitis-Related Genes Across Human Tissues Based on the Summary Mendelian Random-ization. Frontiers In Cell And Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.624766
Zhang, S., Kong, C., Yang, Y., Cai, S., Li, X., Cai, G., & Ma, Y. (2020). Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer. Theranostics, 10(25), 11595-11606. https://doi.org/10.7150/thno.49515
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- Universidad de Bogotá Jorge Tadeo Lozano
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- Universidad de Bogotá Jorge Tadeo Lozano